Greg Joyner

Host-derived markers of Lyme disease and other spirochaetel infections:
Discovery and their diagnostic potential

Personal Statement:

Greg started in the Clinical Surveillance Theme PhD Studentship ‘Host-derived markers of Lyme disease and their diagnostic and prognostic potential’ in October 2015, with supervisors Nick Beeching of the Liverpool School of Tropical Medicine, Julian Hiscox of the University of Liverpool, and Amanda Semper, Tim Brooks and Jackie Duggan of Public Health England.

 

Greg is a graduate in Microbiology from the University of Glasgow, with experience in pathogen detection, and previously worked in drug manufacturing for a pharmaceutical company.

          

Greg Joyner

Lay Summary:

Lyme disease (LD) is an infectious disease caused by bacteria of the Borrelia type.  UK and US laboratory diagnosis of LD involves the two-tier serological approach. The negative predictive value of the test has been challenged, particularly in early stage LD. There is considerable interest, therefore, in the development of improved diagnostic tests.

The main aim of my project is to identify new markers that could form the basis for improved tests. The project investigates the protein composition of the blood of patients with LD (proteomics) compared to healthy controls.  Control samples from patients with related illnesses including lepotspirosis and syphilis will also be included. Gene expression changes in response to LD will also be investigated by using RNA sequencing methods.


Supervisors:

  • Nick Beeching – NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool School of Tropical Medicine
  • Julian A. Hiscox– NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool
  • Amanda Semper - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Public Health England
  • Tim Brooks – NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Public Health England