Publications: 2021

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study

2021
Journal: Lancet
Authors: HPRU Author: Jake Dunning

Communicating uncertainty in epidemic models

2021
Journal: PubMed
Authors: HPRU-EZI Authors - Ruth McCabe; Christl Donnelly

Estimating vaccination threshold and impact in the 2017-2019 hepatitis A virus outbreak among persons experiencing homelessness or who use drugs in Louisville, Kentucky, United States

2021
Journal: Vaccine
Authors: HPRU-EZI Authors - Christl Donnelly

Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort

2021
Journal: eLife
Authors: HPRU-EZI Authors - Jake Dunning; Christl Donnelly; Peter Horby; Mark Pritchard

Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol

2021
Journal: Thorax
Authors: HPRU Authors: Calum Semple; Jake Dunning; Tom Solomon; Peter Horby; Lance Turtle

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

2021
Journal: iScience
Authors: HPRU-EZI Authors: Calum Semple, Lance Turtle

Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study

2021
Journal: NDT
Authors: HPRU-EZI Authors - Calum Semple, Jake Dunning

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

2021
Journal: iScience
Authors: HPRU-EZI Author - Lance Turtle

Transmission dynamics of SARS-CoV-2 in the hospital setting

2021
Journal: PLOS Medicine
Authors: HPRU Author: Christl Donnelly

COVID-19–Associated Orphanhood and Caregiver Death in the United States

2021
Journal: Pediatrics
Authors: HPRU-EZI Authors - Christl Donnelly

Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol

2021
Journal: Lancet
Authors: HPRU-EZI Authors - Calum Semple, Lance Turtle

Differential impact of the COVID-19 pandemic on laboratory reporting of norovirus and Campylobacter in England: A modelling approach. PLoS One [Internet]. 2021;16(8)

2021
Journal: Plos One
Authors: HPRU-EZI Authors - Roberto Vivancos

Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern.

2021
Journal: Nature Communications
Authors: HPRU-EZI Authors - Miles Carroll

A comparison of persistence of SARS-CoV-2 variants on stainless steel

2021
Journal: J Hospital Infections
Authors: HPRU Author: Jake Dunning

Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions

2021
Journal: Journal of Neurology
Authors: HPRU Author: Tom Solomon

Investigation of SARS-CoV-2 Faecal Shedding in the Community: A Prospective Household Cohort Study (COVID-LIV) in the UK - BMC Infectious Diseases (2021) 21:784

2021
Journal: BMC Infectious Diseases
Authors: HPRU-EZI Authors - Adams Emily R. Turtle Lance. Solomon Tom. French Neil.

Considerations for causality assessment of neurological and neuropsychiatric complications of SARS-CoV-2 vaccines: from cerebral venous sinus thrombosis to functional neurological disorder. J Neurol Neurosurg Psychiatry. 2021;jnnp-2021-326924.

2021
Journal: Journal of Neurology, Neurosurgery & Psychiatry
Authors: HPRU-EZI Authors - Tom Solomon.

Cerebral venous thrombosis after vaccination against COVID-19 in the UK: a multicentre cohort study. Lancet. 2021;6736(21):1–10

2021
Journal: The Lancet
Authors: HPRU-EZI Authors - Tom Solomon

Subacute Cognitive Impairment in Individuals With Mild and Moderate COVID-19: A Case Series. Frontiers in Neurology. 2021;12

2021
Journal: Frontiers in Neurology
Authors: HPRU-EZI Authors - Solomon, Tom

Co-Infections, Secondary Infections, and Antimicrobial Usage in Hospitalised Patients with COVID-19 from the ISARIC WHO CCP-UK Study: A Prospective, Multicentre Cohort Study

2021
Journal: Lancet
Authors: HPRU Authors: Calum Semple, Jake Dunning, Lance Turtle

Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort

2021
Journal: Obesity
Authors: HPRU Author: Calum Semple

Protocol for DexEnceph: a randomised controlled trial of dexamethasone therapy in adults with herpes simplex virus encephalitis BMJ Open 2021:11

2021
Journal: BMJ
Authors: HPRU-EZI Authors - TomSolomon.

Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe. Sci Rep [Internet]. 2021;11(1):1–9.

2021
Journal: Scientific Reports
Authors: HPRU-EZI Authors - Crook, Jack M. Carroll, Miles Vipond, Richard

Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study

2021
Journal: Lancet
Authors: HPRU Author: Calum Semple, Lance Turtle, Jake Dunning

One hundred years of zoonoses research in the Horn of Africa: A scoping review. PLoS Negl Trop Dis. 2021;15(7)

2021
Journal: PLOS Neglected Tropical Diseases
Authors: HPRU-EZI Authors - Maya Wardeh, Matthew Baylis,

Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study. Lancet Child Adolesc Heal [Internet]. 2021;4642(21):1–11.

2021
Journal: The Lancet. Child & adolescent health
Authors: HPRU-EZI Authors - Tom Solomon.

Prevalence of neutralising antibodies against SARS-CoV-2 in acute infection and convalescence: A systematic review and meta-analysis. PLoS Negl Trop Dis. 2021;15(7):

2021
Journal: PLOS Neglected Tropical Diseases
Authors: HPRU-EZI Authors - Adams, Emily R., Cuevas, Luis E.

Understanding norovirus reporting patterns in England : a mixed model approach

2021
Journal: BMC Public Health
Authors: HPRU Author: Roberto Vivancos

Divide-and-conquer: machine-learning integrates mammalian and viral traits with network features to predict virus-mammal associations

2021
Journal: Nature Communications
Authors: HPRU Author: Matthew Baylis

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

2021
Journal: Infection
Authors: HPRU Author: Calum Semple

Divergent trajectories of antiviral memory after SARS-Cov-2 infection

2021
Journal: pre print Square Space
Authors: HPRU-EZI Authors - Lance Turtle.

The future of Japanese encephalitis vaccination: expert recommendations for achieving and maintaining optimal JE control

2021
Journal: NPJ Vaccines
Authors: HPRU Author: Tom Solomon

Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions

2021
Journal: Journal of Neurological Sciences
Authors: Thakur, Kiran T. Tamborska, Arina Wood, Greta K. McNeill, Emily Roh, David Akpan, Imo J. Miller, Eliza C. Bautista, Alyssa Claassen, Jan Kim, Carla Y. Guekht, Alla Pardo, Carlos A. Williams, Olajide García-Azorín, David Prasad, Kameshwar Schmutzhard, Erich Michael, Benedict D. Chou, Sherry H.-Y. Winkler, Andrea S. Solomon, Tom Elkind, Mitchell S.

Co-Infections, Secondary Infections, and Antimicrobial Usage in Hospitalised Patients with COVID-19 from the ISARIC WHO CCP-UK Study: A Prospective, Multicentre Cohort- Lancet Microbe

2021
Journal: The Lancet Microbe
Authors: HPRU-EZI Authors - Turtle, Lance Dunning, Jake Semple, Malcolm

Neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives

2021
Journal: Journal of Neurology, Neurosurgery & Psychiatry
Authors: HPRU Author: Tom Solomon

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

2021
Journal: Lancet
Authors: HPRU-EZI Authors: Peter Horby

Blood-feeding ecology of mosquitoes in two zoological gardens in the United Kingdom

2021
Journal: Parasites & Vectors
Authors: HPRU Author: Matthew Baylis

Identifying how COVID-19-related misinformation reacts to the announcement of the UK national lockdown: An interrupted time-series study

2021
Journal: Sage
Authors: HPRU-EZI Authors - Sally Sheard; John Tulloch; Roberto Vivancos

The microbiome and mosquito vectorial capacity: rich potential for discovery and translation

2021
Journal: MIcrobiome
Authors: Cintia Cansado-Utrilla , Serena Y. Zhao , Philip J. McCall , Kerri L. Coon and Grant L. Hughes

Evaluating clinical characteristics studies produced early in the Covid-19 pandemic: A systematic review. PLoS One 2021;16(5)

2021
Journal: PloS one
Authors: HPRU-EZI Authors - Tom Solomon; Peter W Horby; Mark Pritchard

Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK

2021
Journal: The Lancet
Authors: HPRU-EZI Authors: Jake Dunning; Lance Turtle; Peter Openshaw; Malcolm G Semple

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

2021
Journal: Lancet
Authors: HPRU-EZI Author: Peter Horby

Inactivation of SARS-CoV-2 on surfaces and in solution with Virusend (TX-10), a novel disinfectant

2021
Journal: Access Microbiology
Authors: Enyia R. Anderson, Grant L. Hughes, Edward I. Patterson

Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination.

2021
Journal: The New England journal of medicine
Authors: Singh, Deepak, Lown, Robert. Poles, Anthony. Solomon, Thomas. Levi, Marcel. Goldblatt, David. Kotoucek, Pavel. Thomas, William. Lester, William.

Perspectives on COVID-19 testing policies and practices: a qualitative study with scientific advisors and NHS health care workers in England

2021
Journal: BMC Public Health
Authors: Anne-Marie Martindale Caitlin Pilbeam Hayley Mableson Sarah Tonkin-Crine Paul Atkinson Aleksandra Borek Suzie Lant Nina Gobat Tom Solomon Sally Sheard

Approaches to understanding COVID‐19 and its neurological associations

2021
Journal: Annals of Neurology
Authors: Beghi, Ettore Michael, Benedict D. Solomon, Tom Westenberg, Erica Winkler, Andrea S. Beghi, Ettore Michael, Benedict D. Solomon, Tom Westenberg, Erica Winkler, Andrea S. Knauss, Samuel Sejvar, Jim Siddiqi, Omar Netravathi, M Charway‐Felli, Augustina Abd‐Allah, Foad Bassetti, Claudio Ferreira, Maria Lúcia Brito Chou, Sherry Hsiang‐Yi Dalmau, Josep Delgado‐García, Guillermo Easton, Ava Emmrich, Julius Endres, Matthias Fleury, Agnès Frontera, Jennifer A. García‐Azorín, David Guekht, Alla Helbok, Raimund Hellwig, Kerstin Höglinger, Günter Hoo, Fan Kee Klein, Christine Lant, Suzannah McNett, Molly Moro, Elena Padovani, Alessandro Pfausler, Bettina Prasad, Kameshwar Roman, Gustavo C. Sarfo, Fred S. Satishchandra, Parthasarathy Saylor, Deanna Spatola, Marianna Spencer, Peter Stark, Richard J. Synofzik, Matthis Taba, Pille Tagliavini, Fabrizio Thakur, Kiran T. Umapathi, Thirugnanam Vijayabala, Jeevagan Weissenborn, Karin Wijeratne, Tissa Wood MRes, Greta K Carroll, William M. Oreja‐Guevara, Celia Leonardi, Matilde Schmutzhard, Erich

A Haemagglutination test for rapid detection of antibodies to SARS-CoV-2

2021
Journal: Nature Communications
Authors: Townsend, Alain Rijal, Pramila Xiao, Julie Tan, Tiong Kit Huang, Kuan-ying A Schimanski, Lisa Huo, Jiandong Gupta, Nimesh Rahikainen, Rolle Matthews, Philippa C Crook, Derrick Hoosdally, Sarah Dunachie, Susanna Barnes, Eleanor Street, Teresa Semple, Malcolm G Turtle, Lance C W Ainsworth, Mark Allcock, Alice Beer, Sally

Assessing the suitability for Aedes albopictus and dengue transmission risk in China with a delay differential equation model

2021
Journal: PLoS neglected tropical diseases
Authors: Metelmann, Soeren Liu, Xiaobo Lu, Liang Caminade, Cyril Liu, Keke Cao, Lina Medlock, Jolyon M. Baylis, Matthew Morse, Andrew P. Liu, Qiyong

Assessing the suitability for Aedes albopictus and dengue transmission risk in China with a delay differential equation model

2021
Journal: PLoS neglected tropical diseases
Authors: HPRU-EZI Authors - Medlock, Jolyon M. Baylis, Matthew

SARS-CoV-2 Infections in Animals: Reservoirs for Reverse Zoonosis and Models for Study

2021
Journal: Viruses
Authors: Prince, Tessa Smith, Shirley L Radford, Alan D Solomon, Tom Hughes, Grant L Patterson, Edward I

Long-term neurodevelopment outcomes of hand, foot and mouth disease inpatients infected with EV-A71 or CV-A16, a retrospective cohort study

2021
Journal: Emerging Microbes & Infections
Authors: HPRU-EZI Authors- Lance Turtle

Systematic review of pooling sputum as an efficient method for xpert MTB/RIF tuberculosis testing during COVID-19 pandemic. Emerg Infect Dis. 2021;27(3):719–27

2021
Journal: Emerging Infectious Diseases
Authors: HPRU-EZI Authors - Cuevas, Luis E., Adams, Emily

Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol

2021
Journal: BMJ Open
Authors: Setiabudi, Wega Hungerford, Daniel Subramaniam, Krishanthi Vaselli, Natasha Marcella Shaw, Victoria E Wilton, Moon Vivancos, Roberto Aston, Stephen Platt, Gareth Moitt, Tracy Jones, Ashley P Gabbay, Mark Buchan, Iain Carrol, Enitan D Iturriza-Gomara, Miren Solomon, Tom Greenhalf, William Naisbitt, Dean J Adams, Emily R Cunliffe, Nigel A Turtle, Lance French, Neil

Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID‐19: Analysis of the ISARIC CCP‐UK Study. J. Obesity

2021
Journal: Obesity
Authors: HPRU-EZI Authors Semple, Malcolm G.

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

2021
Journal: Science Immunology
Authors: Thwaites, Ryan S Sanchez Sevilla Uruchurtu, Ashley Siggins, Matthew K Liew, Felicity Russell, Clark D Moore, Shona C Fairfield, Cameron Carter, Edwin Abrams, Simon Short, Charlotte-Eve Thaventhiran, Thilipan Bergstrom, Emma Gardener, Zoe Ascough, Stephanie Chiu, Christopher Docherty, Annemarie B Hunt, David Crow, Yanick J Solomon, Tom Taylor, Graham P Turtle, Lance Harrison, Ewen M Dunning, Jake Semple, Malcolm G Baillie, J Kenneth Openshaw, Peter JM

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

2021
Journal: Science-Immunology
Authors: HPRU-EZI Authors: Tom Solomon, Lance Turtle, Calum Semple, Jake Dunning

Torix Rickettsia are widespread in arthropods and reflect a neglected symbiosis

2021
Journal: GigaScience
Authors: Pilgrim, Jack Thongprem, Panupong Davison, Helen Siozios, Stefanos Baylis, Matthew Zakharov, Evgeny V. Ratnasingham, Sujeevan DeWaard, Jeremy R. Smith, M. Alex Hurst, Gregory D. D.

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

2021
Journal: Cell
Authors: HPRU-EZI Author - Calum Semple

Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK

2021
Journal: Lancet
Authors: HPRU-EZI Authors: Calum Semple, Jake Dunning

Long Covid in adults discharged from UK hospitals after Covid-19 : A prospective , multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol Author Affiliations :

2021
Journal: BMJ
Authors: HPRU-EZI Authors - Sigfrid, Louise Goodwin, Lynsey Turtle, Lance Semple, Malcom G

Modelling intensive care unit capacity under different epidemiological scenarios of the COVID-19 pandemic in three Western European countries

2021
Journal: International Journal of Epidemiology
Authors: McCabe R, Kont MD, Schmit N, Whittaker C, Løchen A, Baguelin M,

Predicting mammalian hosts in which novel coronaviruses can be generated

2021
Journal: Nature Communications
Authors: Maya Wardeh Matthew Baylis, Marcus S. C. Blagrove

Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19.

2021
Journal: bioRxiv
Authors: Jordan J. Clark , Rebekah Penrice-Randal , Parul Sharma , Anja Kipar , Xiaofeng Dong , Shaun H. Pennington , Amy E. Marriott , Stefano Colombo , Andrew Davidson , Maia Kavanagh Williamson , David A. Matthews , Lance Turtle , Tessa Prince , Grant L. Hughes , Edward I. Patterson , Ghada Shawli , Krishanthi Subramaniam , Jo Sharp , Lynn McLaughlin , En-Min Zhou , Joseph D. Turner , Giancarlo Biagini , Andrew Owen , Julian A. Hiscox, James P. Stewart

Cardinium symbiosis as a potential confounder of mtDNA based phylogeographic inference in Culicoides imicola (Diptera: Ceratopogonidae), a vector of veterinary viruses. Parasit Vectors [Internet]. 2021;14(1):1–5

2021
Journal: Parasites & Vectors
Authors: HPRU-EZI Authors - Matthew Baylis

Impact of climatic, demographic and disease control factors on the transmission dynamics of COVID-19 in large cities worldwide

2021
Journal: One Health
Authors: Metelmann, Soeren Pattni, Karan Brierley, Liam Cavalerie, Lisa Caminade, Cyril Blagrove, Marcus S.C. Turner, Joanne Sharkey, Kieran J. Baylis, Matthew

Ebola virus antibody decay – stimulation in a high proportion of survivors

2021
Journal: Nature
Authors: Adaken, Charlene Scott, Janet T Sharma, Raman Gopal, Robin Dicks, Steven Niazi, Saidia Ijaz, Samreen Edwards, Tansy Smith, Catherine C Cole, Christine P

Mayaro Virus Infection Elicits an Innate Immune Response and Represses Autophagy in Anopheles stephensi

2021
Journal:
Authors: Cory Henderson, Marco Brustolin, Shivanand Hegde, Grant L. Hughes, Christina Bergey, Jason L. Rasgon

English hospital episode data analysis (1998–2018) reveal that the rise in dog bite hospital admissions is driven by adult cases

2021
Journal: Nature
Authors: John S. P. Tulloch 1,2,3*, Sara C. Owczarczak‐Garstecka 3,4,5, Kate M. Fleming 6, Roberto Vivancos 2,7 & Carri Westgarth 3

COVID-19 testing in outbreak free care homes: What are the public health benefits?

2021
Journal: Journal of Hospital Infection
Authors: Green, R. Tulloch, J.S.P. Tunnah, C. Coffey, E. Lawrenson, K. Fox, A. Mason, J. Barnett, R. Constantine, A. Shepherd, W. Ashton, M. Beadsworth, M.B.J. Vivancos, R. Hall, I. Walker, N. Ghebrehewet, S.

Analysis of an Ebola virus disease survivor whose host and viral markers were predictive of death indicates the effectiveness of medical countermeasures and supportive care

2021
Journal: Genome Medicine
Authors: Bosworth, Andrew Rickett, Natasha Y. Dong, Xiaofeng Ng, Lisa F.P. García-Dorival, Isabel Matthews, David A. Fletcher, Tom Jacobs, Michael Thomson, Emma C. Carroll, Miles W. Hiscox, Julian A.

Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study

2021
Journal: The Lancet
Authors: HPRU-EZI Authors: Tom Solomon, Lance Turtle, Calum Semple, Jake Dunning

Neurological infection with SARS-CoV-2 — the story so far

2021
Journal: Nature Reviews Neurology
Authors: Solomon, Tom