The overarching aim of the HPRU is to support and strengthen PHE in its role of protecting England from emerging and zoonotic infections. By bringing together internationally leading researchers at the University of Liverpool (UoL), University of Oxford, Liverpool School of Tropical Medicine (LSTM) and PHE, we exploit the synergy, world-class facilities, and breadth and depth in relevant research between these institutions.


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The COVID Hot Potato 9
This week the hottest ‘hot potato’ is the open letter in the British Medical Journal from the Presidents of Royal Colleges calling for a rapid review of preparations for a second wave of COVID-19, and a focus on areas of weakness where action is needed to prevent further loss of life.

Posted on: 25/06/2020

Submission to PAC on readying NHS and social care for COVID-19 peak
NIHR HPRU EZI submits to PAC on readying NHS and social care for COVID-19 peak

Posted on: 22/06/2020

Dexamethasone reduces death in hospitalised patients
HPRU EZI's Prof Peter Horby leads study that shows Dexamethasone reduces death in hospitalised patients with severe respiratory complications of COVID

Posted on: 17/06/2020

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BMJ Best Practice Coronavirus Disease (COVID-19)
Nicholas J Beeching, Tom E Fletcher, Robert Fowler
BMJ Best Practice, 

Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site
Andrew D. Davidson, Maia Kavanagh Williamson, Sebastian Lewis, Deborah Shoemark, Miles W. Carroll, Kate Heesom, Maria Zambon, Joanna Ellis, Phillip A. Lewis, Julian A. Hiscox,  View ORCID ProfileDavid A. Matthews

Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19
Shona C Moore, Rebekah Penrice-Randal, Muhannad Alruwaili, Xiaofeng Dong, Steven T Pullan, Daniel Carter, Kevin Bewley, Qin Zhao, Yani Sun, Catherine Hartley, En-min Zhou, Tom Solomon, Michael B. J. Beadsworth, James Cruise, Debby Bogaert, Derrick W T Crook, View ORCID ProfileDavid A Matthews, Andrew D. Davidson, Zana Mahmood, Waleed Aljabr, Julian Druce, Richard T Vipond, Lisa Ng, Laurent Renia, Peter Openshaw, View ORCID ProfileJ Kenneth Baillie, Miles W Carroll, Calum Semple, Lance Turtle, Julian Alexander Hiscox

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