The overarching aim of the HPRU is to support and strengthen PHE in its role of protecting England from emerging and zoonotic infections. By bringing together internationally leading researchers at the University of Liverpool (UoL), University of Oxford, Liverpool School of Tropical Medicine (LSTM) and PHE, we exploit the synergy, world-class facilities, and breadth and depth in relevant research between these institutions.


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Submission to House of Lords Public Services Committee
In this submission we focus on the relationship between local and national services. The UK response to the pandemic has been characterised – to a greater extent than in some similar countries – by large central initiatives employing private contractors. Certain services, such as testing, had to be very rapidly expanded, and – rightly or wrongly – public sector bodies in the UK had not been funded to put sufficient ‘surge’ capacity in place beforehand. We would draw attention to two linked issues: the merits of a centralised response, and the use of private contractors.

Posted on: 20/07/2020

COVID-19 brain complications found across the globe
Cases of brain disease linked to COVID-19 are occurring across the globe, a new review by NIHR HPRU EZI researchers at the University of Liverpool has shown.

Posted on: 08/07/2020

Launch of the innovative COVID-19 drug testing platform AGILE
Liverpool School of Tropical Medicine, the University of Liverpool and Southampton Clinical Trials Unit announced this week that they have launched their innovative COVID-19 drug testing platform, AGILE.

Posted on: 08/07/2020

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BMJ Best Practice Coronavirus Disease (COVID-19)
Nicholas J Beeching, Tom E Fletcher, Robert Fowler
BMJ Best Practice, 

Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site
Andrew D. Davidson, Maia Kavanagh Williamson, Sebastian Lewis, Deborah Shoemark, Miles W. Carroll, Kate Heesom, Maria Zambon, Joanna Ellis, Phillip A. Lewis, Julian A. Hiscox,  View ORCID ProfileDavid A. Matthews

Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19
Shona C Moore, Rebekah Penrice-Randal, Muhannad Alruwaili, Xiaofeng Dong, Steven T Pullan, Daniel Carter, Kevin Bewley, Qin Zhao, Yani Sun, Catherine Hartley, En-min Zhou, Tom Solomon, Michael B. J. Beadsworth, James Cruise, Debby Bogaert, Derrick W T Crook, View ORCID ProfileDavid A Matthews, Andrew D. Davidson, Zana Mahmood, Waleed Aljabr, Julian Druce, Richard T Vipond, Lisa Ng, Laurent Renia, Peter Openshaw, View ORCID ProfileJ Kenneth Baillie, Miles W Carroll, Calum Semple, Lance Turtle, Julian Alexander Hiscox

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