Diagnostic and Host Response Studies

Risk Assessment

Improving diagnostics is central to the delivery of the mission of PHE to respond to infectious diseases, the threats they pose and to inform disease management strategies. Whilst great progress has been made in the use of nucleic acid-based detection strategies, development of serologic approaches have lagged, despite their unique capability to confirm infection in the absence of nucleic acid. Genomic approaches have shown the utility of characterising the host response to inform triage of patients. Further work is required to validate these methodologies, particularly to investigate the predictive power of unique molecular signatures and to correlate these with patient data and improve case management protocols. This Theme brings together a multidisciplinary team to characterise pathogen and host biology and use this information to develop new versatile platforms to diagnose infection and inform case management.

Theme Leader and Theme Co-Leads

 Julian Hiscox

Professor Julian Hiscox

Theme Lead

Institute of Infection and Global Health, University of Liverpool



Miles Carroll

Professor Miles Carroll

Theme Co-Lead Public Health England




Emily Adams

Dr Emily Adams

Theme Co-Lead Liverpool School of Tropical Medicine



 Peter Simmonds

Professor Peter Simmonds

Theme Co-Lead University of Oxford













Dr Richard Vipond
Public Health England

Paul Klenerman

Professor Paul Klenerman

University of Oxford


    Derrickcrook Fit 204X204

Prof Derrick Crook

University of Oxford


Mike Griffiths

Dr Mike Griffiths

Reader and Hon Paediatric Neurology Consultant
University of Liverpool

PhD Student: