Approaches to understanding COVID‐19 and its neurological associations


Beghi, Ettore Michael, Benedict D. Solomon, Tom Westenberg, Erica Winkler, Andrea S. Beghi, Ettore Michael, Benedict D. Solomon, Tom Westenberg, Erica Winkler, Andrea S. Knauss, Samuel Sejvar, Jim Siddiqi, Omar Netravathi, M Charway‐Felli, Augustina Abd‐Allah, Foad Bassetti, Claudio Ferreira, Maria Lúcia Brito Chou, Sherry Hsiang‐Yi Dalmau, Josep Delgado‐García, Guillermo Easton, Ava Emmrich, Julius Endres, Matthias Fleury, Agnès Frontera, Jennifer A. García‐Azorín, David Guekht, Alla Helbok, Raimund Hellwig, Kerstin Höglinger, Günter Hoo, Fan Kee Klein, Christine Lant, Suzannah McNett, Molly Moro, Elena Padovani, Alessandro Pfausler, Bettina Prasad, Kameshwar Roman, Gustavo C. Sarfo, Fred S. Satishchandra, Parthasarathy Saylor, Deanna Spatola, Marianna Spencer, Peter Stark, Richard J. Synofzik, Matthis Taba, Pille Tagliavini, Fabrizio Thakur, Kiran T. Umapathi, Thirugnanam Vijayabala, Jeevagan Weissenborn, Karin Wijeratne, Tissa Wood MRes, Greta K Carroll, William M. Oreja‐Guevara, Celia Leonardi, Matilde Schmutzhard, Erich


There is an accumulating volume of research into neurological manifestations of COVID-19. However, inconsistent study designs, inadequate controls, poorly-validated tests, and differing settings, interventions, and cultural norms weaken study quality, comparability, and thus the understanding of the spectrum, burden and pathophysiology of these complications. Therefore, a global COVID-19 Neuro Research Coalition, together with the WHO, has reviewed reports of COVID-19 neurological complications and harmonised clinical measures for future research. This will facilitate well-designed studies using precise, consistent case definitions of SARS-CoV2 infection and neurological complications, with standardised forms for pooled data analyses that non-specialists can use, including in low-income settings. This article is protected by copyright. All rights reserved.


Annals of Neurology



Research Themes:

1. Patient Research for Public Health